The Peroxynitrite Catalyst WW-85 Improves Pulmonary Function in Ovine Septic Shock

The pulmonary ultrastructure in septic shock.

Liver function in septic shock.

Serum liver function tests were estimated in 57 patients admitted to an Intensive Therapy Unit (ITU) with a diagnosis of septic shock. Following an initial biochemical disturbance, persisting hyperbilirubinaemia was associated with a poor prognosis. Post-mortem liver histology in 22 patients showed varying degrees of non-specific reactive change, venous congestion, ischaemic necrosis, fatty cha...

Effects of FP15, a peroxynitrite decomposition catalyst on cardiac and pulmonary function after cardiopulmonary bypass.

OBJECTIVE Peroxynitrite, a toxic nitrogen species, has been implicated in the development of ischemia/reperfusion injury. The aim of the present study was to investigate the effects of the potent peroxynitrite decomposition catalyst, FP15, on myocardial, endothelial, and pulmonary function in an experimental model of cardioplegic arrest and extracorporal circulation. METHODS Twelve anesthetiz...

Adrenal function in sepsis and septic shock.

OBJECTIVE To review diagnostic criteria and treatment of adrenal insufficiency in pediatric patients with severe sepsis and septic shock. SOURCES Articles were selected using MEDLINE (1966-June 2007), Embase (1994-2007) and Cochrane Library (2000-2007) databases. following key words were utilized: septic shock, sepsis, corticosteroids, adrenal insufficiency and children. SUMMARY OF THE FIND...

Cardiac function in pediatric septic shock survivors.

OBJECTIVE To evaluate the long-term effects of septic shock on cardiac function in children treated with inotropic and/or vasoconstrictive agents for 24 hours or longer. DESIGN Cohort study. SETTING Tertiary pediatric intensive care unit and outpatient follow-up clinic. PARTICIPANTS One hundred eight of 144 eligible children who were admitted to our tertiary pediatric intensive care unit ...